Lecture 3

• NaBH3CN Pros

  More selective (weak)

  best way to make secondary amines
• NaBH3CN- why selective?


  only reduces most electrophilic substrates
• Reduction of carbonyls- Aldehydes reduced to


  Primary alcohols
• Reduction of carbonyls- Ketones reduced to


  Secondary alcohols
• NaBH4(reduction)


  Safe

  Mild

  not as reactive
• LiAlH4(reduction)


  Powerful

  hazardous

  slow

  requires dry solvents