Lecture 1

• Jones Reagent- What is it?


  Na2Cr2O7 and sulfuric acid and acetone
• Jones reagent- importance of acetone


  Modifies reactivity of chromium
• Jones reagent- what for


  Secondary alcohols
• Jones reagent Pros


  Oxidises double bonds
• Jones reagent limitations


  Over oxidation, uses a strong acid, toxic
• PCC- what does it oxidise


  Alcohol to aldehyde
• PDC what does it oxidise


  Allylic alcohol to aldehyde
• PDC/PCC Pros


  Oxidises in the absence of water
• PDC/PCC Cons


  Difficult to separate chromium residue from product

  toxic

  large amounts of chromium waste
• TPAP driving force


  Ru(VII) to Ru(V)
• What does TPAP require


  Stoichiometric NMO
• TPAP Con


  Expensive
• MnO2 (MN(IV)) oxidises what


  Can only oxidise activated alcohols

  -Allylic alcohols

  -benzylic alcohols